A new wave of COVID-19, driven by the Omicron subvariants Nimbus (NB.1.8.1) and Stratus (XFG), is leading to a gradual increase in cases globally, with a notable impact on children. According to Dr. Süleyman Alpar of Memorial Bahçelievler Hospital, the current outbreak presents predominantly as an upper respiratory tract infection, with symptoms closely mirroring seasonal flu. The Nimbus variant is particularly distinguished by a uniquely severe “razor-like” sore throat.

Data from the World Health Organization and the United States indicate a rise in test positivity and emergency room visits among vulnerable groups, especially children aged 0-4, corresponding with the start of the school year. Despite this increase in cases, hospitalization and mortality rates have remained low. Due to significant symptom overlap with other respiratory viruses, international guidelines emphasize the necessity of diagnostic confirmation through PCR or rapid antigen testing rather than relying on clinical presentation alone. Special caution and vaccine booster doses are recommended for children with chronic illnesses or compromised immune systems.

Children’s COVID Nimbus Variant and Symptoms course provides a detailed review of COVID  as it pertains to the competencies required for graduation as a doctor of medicine or pharmacy. Increasingly, the basic sciences are taught alongside clinical science, often organ by organ. This course can help students in such integrated curricula gain a discipline-specific understanding of Children’s COVID, particularly Nimbus Variant and Symptoms. The textbook is structured so that it is useful for both the novice and the student who needs a quick review in preparation for licensure exams. The chapters are extensively cross-referenced so the material can be used in almost any chapter sequence. Descriptions of disease states are a regular part of the textbook rather than an addendum in the margin. Students often find it challenging to use their knowledge of basic science to solve clinical problem. Textbooks of Courses will help students build mental bridges between basic science and clinical practice.

The chapters have a structure that makes it easy for the reader to decide what to read and review:

– The Synopsis is an introductory overview of the content of the chapter that requires very little preexisting knowledge.

– The Learning Objectives indicate what the reader should be able to do when mastering the material presented in the chapter.

– Each section starts with a preview.

– Selected terms are printed in bold to make it easier to find relevant text when starting from the index.

– The diagrams contain only the most essential information.

– The Summary provides a brief overview of the chapter material for the expert.

– A Further Reading section provides the reader with a starting point to satisfy deeper interests.

– Review Questions provide the reader with an opportunity to apply newly acquired knowledge. Answers to these questions are at the end of the course.

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The authors dedicate this course to their many students who have been a source of stimulation over the years, and to their many colleagues whose research and insight has resulted in the knowledge described herein. We are also grateful to many educators and institutions that have adopted this text in their courses.

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